Enabling transformative research and teaching initiatives

    • Image of melanoma tumor
      Confocal microscope image of a melanoma tumor. Nuclei are blue, tumor associated macrophages are green and vasculature is red. (Bosenberg and O'Hern labs)
    • Sackler Discussion Group
      A meeting of the monthly Sackler Discussion Group seminar series focusing on research-in-progress talks.
    • Image of IGPPEB students working together
      Graduate students from the biological and the physical science working together in one of the Integrated Workshop hands-on modules that is part of Yale's Integrated Graduate Program in Physical and Engineering Biology.
    • Image of luncheon after visiting speaker
      Luncheon following the seminar of a visiting faculty. Such luncheons help form a tightly-knit interdisciplinary community through networking.
    • Image of REU participant giving a talk
      Sackler/NSF REU participant is giving a talk on the research he conduced in the Horsley lab.
    • Image of students working in groups
      Hands-on workshop run by visiting faculty speakers Profs. David and Jane Richardson, on the capabilities and uses of various software suites.
    • Image of Sackler Undergraduate Research Symposium
      Sackler Undergraduate Research Symposium - the culminating event in Yale's Sackler/NSF REU program.
    • Image of Dr. Raymond Sackler during the 2012 Sackler Symposium
      Dr. Raymond Sackler talking with researchers during the 2012 Sackler Symposium.
    • Image of plate with fluorescent bacteria
      Bacteria expressing a fluorescent protein, isolated from warm water coral and engineered to be brigther than the enhanced green fluorescent protein (Regan lab).
    • Image of microfluidics setup
      A microfluidics setup, which comprised part of a demonstration during the 2012 annual meeting of the NSF Physics of Living Systems Student Research Network, hosted at Yale.
    • Image of optics
      Part of a setup to conduct single molecule fluorescence measurements.
    • Image of force versus extension measurements
      Force versus extension measurements of nucleosomes using a single molecule spectroscopy setup (Mochrie lab).



A generous gift from Dr. Raymond and Mrs. Beverly Sackler (pictured to the right ) allowed the establishment of an institute for the biological, physical and engineering sciences in the fall of 2008. The Raymond and Beverly Sackler Institute for Biological, Physical and Engineering Sciences brings together faculty from the Faculty of Arts and Sciences, The School of Medicine, and the School of Engineering and Applied Sciences enabling transformative research and teaching initiatives. Members of the Sackler Institute are committed to a new paradigm that transcends traditional boundaries both between disciplines and between research, teaching, and learning. We have a variety of programs set in place that showcase the innovative ways in which we achieve this.


Currently, there are 50 faculty members across 20 departments affiliated with the Institute. Many of the faculty have ongoing research collaborations, which focus on exploring a variety of exciting problems in biology using quantitative, physical approaches.


The research of Institute faculty encompass a broad range of time and length scales and frequently bring together wet lab work with theory, computation, and modeling.  Labs affiliated with the Institute explore one or more of the following research thrusts:

  • cellular shape and motion
  • force generation and sensing
  • systems and synthetic biology
  • informatics & data mining
  • cell fate
  • modeling biological processes
  • biomaterials and bioinspired design
  • method development

Current initiatives of the Sackler Institute are closely coordinated with Yale’s Integrated Graduate Program in Physical and Engineering Biology (IGPPEB).


Anyone whose research or teaching interests mesh with the vision of the Sackler Institute is welcome to participate and suggest new initiatives.